Fig. 12

Lipocalin-type DAases can catalyze the generation of four diastereomeric decalin cores of pyrrolidine-2-one-bearing decalin natural products from an achiral linear polyene polyketide substrate [115]. Equisetin-forming Fsa2 represents the 2 S,3R,6 S,11R trans-decalin core-forming DAases. Sch 210,972-forming CghA and phomasetin-forming Phm7 represent the 2R,3 S,6R,11 S trans-decalin core-forming DAases, while varicidin A-forming PvhB represents the 2R,3R,6 S,11 S cis-decalin core-forming DAases. Only the 2 S,3 S,6R,11R cis-decalin core-forming DAase remains to be discovered