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Table 2 Characterization of KEP types

From: Peptides derived from Kex2-processed repeat proteins are widely distributed and highly diverse in the Fungi kingdom

Labela Type IDb Count
FRiPS factors Strains KEPs per strain Genera Phyla Yeast α-mating factorsc Fungal pheromonesd With DUF3328e Without DUF3328f Genera Phyla HMM profiles
Top 8 types sorted by number of KEPs per strain   
 S-1 #22 37 2 18.50 1 1 0 0 0 37 Peniophora Basidiomycota DUF5109, NifZ, YukD
 S-2 #139 8 1 8.00 1 1 0 0 0 8 Hypsizygus Basidiomycota SseB_C, FACT-Spt16_Nlob, DUF445
 S-3 #158 7 1 7.00 1 1 0 0 0 7 Basidiobolus Zoopagomycota  
 S-4 #171 7 1 7.00 1 1 0 0 0 7 Fibularhizoctonia Basidiomycota TOM13, ribosomal_L24
 S-5 #80 12 2 6.00 1 1 0 0 8 4 Sistotremastrum Basidiomycota DUF4170, Eryth_link_C, DUF3756
 S-6 #91 11 2 5.50 2 1 0 0 0 11 Neocallimastix, Piromyces Chytridiomycota Chitin_bind_1
 S-7 #107 10 2 5.00 1 1 0 0 0 10 Batrachochytrium Chytridiomycota  
 S-8 #203 5 1 5.00 1 1 0 0 1 4 Rickenella Basidiomycota  
Top 10 types sorted by number of genera having KEPs   
 G-1/P-2 #7 64 62 1.03 49 2 0 0 0 64 Termitomyces, Moniliophthora, Auriculariopsis, Crucibulum, Trametes, Sphaerobolus, Laccaria, Hypsizygus, Sanghuangporus, Hypholoma, Gloeophyllum, Pleurotus, Dichomitus, Armillaria, Laetiporus, Lentinus, Coprinopsis, Heliocybe, Dendrothele, Panaeolus, Phlebiopsis, Peniophora, Schizopora, Hebeloma, Pterula, Galerina, Schizophyllum, Ganoderma, Antrodiella, Pyrrhoderma, Bondarzewia, Rickenella, Obba, Postia, Pluteus, Neolentinus, Polyporus, Plicaturopsis, Punctularia, Heterobasidion, Dentipellis, Gymnopilus, Stereum, Fibularhizoctonia, Fibroporia, Cyphellophora, Grifola, Fomitiporia, Gelatoporia Basidiomycota, Ascomycota E_Pc_C, Pab87_oct, Osteoregulin, ATXN-1_C, ChlamPMP_M, Cytomega_UL20A, DUF4452, DUF5542, TubC_N, TruB_N, TruB_C, MATH, DUF2188, Motilin_assoc, Sid-5, Str_synth, B_lectin, Phage-tail_3, DUF1648, DUF421, UPF0258, CSD2, SspK, DNA_gyraseA_C, FtsK_alpha, TAFH, gp37_C
 G-2 #2 138 137 1.01 35 1 0 121 1 137 Diplocarpon, Botryotinia, Fusarium, Phialocephala, Pseudogymnoascus, Verticillium, Botrytis, Metarhizium, Coleophoma, Purpureocillium, Lachnellula, Marssonina, Coniella, Trichoderma, Neurospora, Rutstroemia, Sporothrix, Monilinia, Ophiostoma, Pezoloma, Sclerotinia, Sphaerosporella, Colletotrichum, Amorphotheca, Coniochaeta, Thermothielavioides, Podospora, Madurella, Escovopsis, Hyaloscypha, Scytalidium, Chlorociboria, Venustampulla, Cadophora, Sodiomyces Ascomycota Trefoil, DUF2390, Trypan_PARP, PknG_rubred
 G-3 #6 64 59 1.08 20 1 0 0 57 7 Botryotinia, Phialocephala, Botrytis, Lachnellula, Trichoderma, Rutstroemia, Pezoloma, Hyaloscypha, Scytalidium, Cadophora, Penicillium, Rhynchosporium, Talaromyces, Fonsecaea, Verruconis, Capronia, Cladophialophora, Phialophora, Exophiala, Oidiodendron Ascomycota  
 G-4 #1 191 181 1.06 20 1 174 0 0 191 Saccharomyces, Cyberlindnera, Lachancea, Nakaseomyces, Kazachstania, Kluyveromyces, Naumovozyma, Wickerhamomyces, Zygosaccharomyces, Clavispora, Tetrapisispora, Eremothecium, Debaryomyces, Hanseniaspora, Vanderwaltozyma, Millerozyma, Torulaspora, Saccharomycodes, Metschnikowia, Suhomyces Ascomycota CLP1_P, Ribos_L4_asso_C, Cytochrome_P460, MF_alpha_N, MF_alpha, Phage_1_1
 G-5/P-1 #24 35 33 1.06 19 3 0 0 16 19 Botryotinia, Botrytis, Coleophoma, Rutstroemia, Sclerotinia, Colletotrichum, Aspergillus, Penicillium, Dendrothele, Bondarzewia, Pluteus, Heterobasidion, Phialemoniopsis, Cordyceps, Beauveria, Parastagonospora, Leptosphaeria, Psilocybe, Blyttiomyces Ascomycota, Basidiomycota, Chytridiomycota CW_binding_1, DUF1871, Fe_hyd_SSU, HTH_19, ESSS, Fibrinogen_BP, DUF3976, Nuc_N, RHS_repeat, ATP1G1_PLM_MAT8, SHS2_FTSA
 G-6 #13 49 43 1.14 19 1 0 0 46 3 Pseudogymnoascus, Rutstroemia, Colletotrichum, Aspergillus, Penicillium, Rhynchosporium, Talaromyces, Chaetomium, Cordyceps, Blastomyces, Paracoccidioides, Monosporascus, Hypoxylon, Histoplasma, Emergomyces, Beauveria, Torrubiella, Emmonsia, Ophiocordyceps Ascomycota ID, Fibrinogen_BP, CRA_rpt, CAP160, FliC, DUF4485, Novirhabdo_Nv
 G-7 #12 50 48 1.04 18 1 0 0 1 49 Verticillium, Neurospora, Colletotrichum, Thermothielavioides, Sodiomyces, Aspergillus, Capronia, Exophiala, Phaeoacremonium, Valsa, Cytospora, Phialemoniopsis, Gaeumannomyces, Magnaporthiopsis, Thermothelomyces, Umbilicaria, Chaetomium, Eurotiomycetes Ascomycota SAP, Hydrophobin_2, Ish1, HeH, Slx4
 G-8 #15 49 48 1.02 18 1 0 0 45 4 Pseudogymnoascus, Sporothrix, Colletotrichum, Coniochaeta, Thermothielavioides, Phialemoniopsis, Pyrenophora, Pyricularia, Grosmannia, Stagonospora, Parastagonospora, Paraphaeosphaeria, Bipolaris, Exserohilum, Epicoccum, Ascochyta, Pyrenochaeta, Periconia Ascomycota PAP_assoc, WHH
 G-9 #16 48 48 1.00 14 1 0 0 0 48 Phialocephala, Verruconis, Pyrenophora, Parastagonospora, Bipolaris, Exserohilum, Epicoccum, Ascochyta, Pyrenochaeta, Pestalotiopsis, Alternaria, Stemphylium, Corynespora, Venturia Ascomycota CARD_2, T2SSM_b, DUF3953
 G-10 #19 45 45 1.00 11 1 0 0 41 4 Metarhizium, Neurospora, Aspergillus, Penicillium, Zymoseptoria, Cordyceps, Beauveria, Ophiocordyceps, Sordaria, Ustilaginoidea, Pseudocercospora Ascomycota DUF2020, VIT, DUF3983
Top 7 types sorted by number of phyla having KEPsg   
 G-5/P-1 #24 35 33 1.06 19 3 0 0 16 19 Botryotinia, Botrytis, Coleophoma, Rutstroemia, Sclerotinia, Colletotrichum, Aspergillus, Penicillium, Dendrothele, Bondarzewia, Pluteus, Heterobasidion, Phialemoniopsis, Cordyceps, Beauveria, Parastagonospora, Leptosphaeria, Psilocybe, Blyttiomyces Ascomycota, Basidiomycota, Chytridiomycota CW_binding_1, DUF1871, Fe_hyd_SSU, HTH_19, ESSS, Fibrinogen_BP, DUF3976, Nuc_N, RHS_repeat, ATP1G1_PLM_MAT8, SHS2_FTSA
 G-1/P-2 #7 64 62 1.03 49 2 0 0 0 64 Termitomyces, Moniliophthora, Auriculariopsis, Crucibulum, Trametes, Sphaerobolus, Laccaria, Hypsizygus, Sanghuangporus, Hypholoma, Gloeophyllum, Pleurotus, Dichomitus, Armillaria, Laetiporus, Lentinus, Coprinopsis, Heliocybe, Dendrothele, Panaeolus, Phlebiopsis, Peniophora, Schizopora, Hebeloma, Pterula, Galerina, Schizophyllum, Ganoderma, Antrodiella, Pyrrhoderma, Bondarzewia, Rickenella, Obba, Postia, Pluteus, Neolentinus, Polyporus, Plicaturopsis, Punctularia, Heterobasidion, Dentipellis, Gymnopilus, Stereum, Fibularhizoctonia, Fibroporia, Cyphellophora, Grifola, Fomitiporia, Gelatoporia Basidiomycota, Ascomycota E_Pc_C, Pab87_oct, Osteoregulin, ATXN-1_C, ChlamPMP_M, Cytomega_UL20A, DUF4452, DUF5542, TubC_N, TruB_N, TruB_C, MATH, DUF2188, Motilin_assoc, Sid-5, Str_synth, B_lectin, Phage-tail_3, DUF1648, DUF421, UPF0258, CSD2, SspK, DNA_gyraseA_C, FtsK_alpha, TAFH, gp37_C
 P-3 #165 7 7 1.00 5 2 0 0 4 3 Fonsecaea, Cladophialophora, Galerina, Psilocybe, Coprinellus Ascomycota, Basidiomycota  
 P-4 #108 10 6 1.67 3 2 0 0 0 10 Rhizophagus, Diversispora, Trichomonascus Mucoromycota, Ascomycota Apidaecin
 P-5 #245 5 5 1.00 3 2 0 0 0 5 Pterula, Puccinia, Batrachochytrium Basidiomycota, Chytridiomycota FKBP_C
 P-6 #205 5 4 1.25 2 2 0 5 0 5 Yarrowia, Cutaneotrichosporon Ascomycota, Basidiomycota CTD
 P-7 #26 35 33 1.06 2 2 0 0 0 35 Talaromyces, Cryptococcus Ascomycota, Basidiomycota  
  1. aCorresponding to those in Fig. 5
  2. bCorresponding to those in Additional file 3: Table S2
  3. cThose having MF_alpha and/or MF_alpha_N HMM profiles as listed in Additional file 3: Table S2
  4. dThose annotated as pheromones in the NCBI database but not “yeast a-mating factors”, as listed in Additional file 3: Table S2
  5. eThose having the genes encoding DUF3328 domain-containing proteins within 15 genes
  6. fThose having no genes encoding DUF3328 domain-containing proteins within 15 genes
  7. gOmitted types including KEPs from 2 unclassified strains from this comparison
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