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Fig. 6 | Fungal Biology and Biotechnology

Fig. 6

From: Bidirectional histone-gene promoters in Aspergillus: characterization and application for multi-gene expression

Fig. 6

Chemical analysis of malformin producing strains. The putative malformin producing BGC is conserved between producing species in Aspergillus section Nigri and the BGC organization is shown in the top of the figure. For the chemical analysis, three EICs illustrate the malformin-production capabilities in three individual strain types. The top panel shows the expression of mlfA (Oex-mlfA) alone is sufficient to produce malformin although the production comes at a price of reduced fitness and sporulation. In the middle, the residual part of the putative BGC (rBGC or rBGC*) has been integrated, and production remains at the same level as in the top, however the phenotype has been restored to normal for both constructs. Bottom panel shows that the reference strain of A. nidulans do not produce malformin, as it does not possess the malformin BGC. In the bottom of the figure, the enzyme types representing the genes within the BGC are listed with color codes matching the gene arrows

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