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Fig. 1 | Fungal Biology and Biotechnology

Fig. 1

From: Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Fig. 1

Chemical structures of calbistrin and related metabolites and UHPLC-HRMS analysis of P. decumbens wild type and PKS mutant strains. a Chemical structures of (1) calbistrin A, (2) calbistrin C, (3) putative linear moiety, (4) decumbenone A, (5) decumbenone B, (6) decumbenone C, and in the box compactin and lovastatin. b UHPLC-HRMS analysis of the wild type P. decumbens culture extract. Merged extracted ion chromatograms (EICs), ± m/z 0.005 of molecular features detected for compounds 1–6: 263.1642; 281.1742; 321.1670; 337.1401; 245.1177; 303.1204; 247.1697; 265.1806; 305.1720; 245.1538; 303.1575; 319.1331; 505.2591; 523.2705; 563.2622; 525.2847; 565.2776; and 285.1463. Additionally, the EIC of andrastin C (m/z 473.2898) is shown in orange. Calbistrin A and andrastin C were confirmed with a reference standard (marked with *), the other compounds were tentative identified based on UV-spectra and MS/HRMS fragmentation patterns. c UHPLC-HRMS results of P. decumbens ∆PKS culture extract. Merged EICs of molecular features detected for compounds 1-7 and EIC of andrastin C as in B

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