Table 1 The enzyme(s) required for synthesizing the carbon backbone for each specialized metabolite are highlighted in bold

Polyketides

 Aflatoxin

Mycotoxin

AflD (KR), AflH (DH), AflM (OXR), AflK (CYC), AflP (MT)

AflA (FAS), AflB (FAS), AflC (PKS),

HypC (OX)

AflaR (TF),

AflaJ (TF)

AflK (CYC)

AflK (CYC)

AflD (KR),

AflP (MT),

AflaR (TF),

AflaJ (TF)

 Melanin

Photo- protectant / virulence factor

BcBRN1 (Red),

BcBRN2 (Red),

BcPKS12 (PKS),

BcPKS13 (PKS),

BcYGH1 (HYD)

Alb1 (PKS),

Agy1 (HYD),

Arp1 (DH),

Arp2 (Red)

Abr1 (OX),

Abr2 (Lac),

WA (PKS)

YA (Lac)

BcBRN1 (Red),

BcBRN2 (Red),

BcSCD1 (DH),

BcBRN1 (Red),

BcBRN2 (Red),

 Patulin

Mycotoxin

PatK (PKS),

PatG (DCL),

PatN (DH),

PatF (U),

PatD (DH),

PatB (CE)

PatL (TF)

PatA (transporter),

PatH (P450),

PatI (P450)

PatJ (U),

PatO (OXR),

PatC (MFS),

PatM (ABC),

PatE (OXR),

PatC (MFS),

PatM (ABC)

PatE (OXR)

 Viriditoxin

Bacterial cell division inhibitor

VdtG (MFS)

VdtA (PKS)

 AK-Toxin

Mycotoxin

AKT1 (CA),

AKT2 (HYD),

AKT3 (ECH)

 Fumonisin

Mycotoxin (ceramide synthase inhibitor)

Fum3 (OX)

Fum21p (TF)

Fum8 (AMT),

Fum17 (CS),

Fum18 (CS),

Cer1 (CS)

 A26771B

Antibiotic

BerkC (SDR)

BerkF (AT)

BerkD (OXR)

Terpenes

 Trichothecene

Mycotoxin

Tri5 (TC),

Hms1 (HMGS)

Tri6 (TF), Tri10 (TF)

Tri 1(P450),

Tri4 (P450),

Tri11 (P450),

Tri14 (U),

Red (P450R),

Hmr1 (HMGR)

Tri5 (TC),

 Gibberellic acid

Phytohormone

Cs/Ks (TC)

HmgR (HMGR)

Ggs2 (GGPS)

 Paxilline

Mycotoxin

PaxG (GGPS)

 Aphidicolin

DNA polymerase inhibitor

PbACS (TC), PbGGS (GGPS)

PbP450-1 (P450), PbP450-2 (P450)

Mixed

 Mycophenolic acid

Immunosuppressant agent

MpaC’ (PKS),

MpaG’ (MT)

PbACL891 (ACL),

MpaH’ (ACH)

MpaDE’ (P450 / HYD),

MpaB’ (OX),

MpaA’ (PT)

Peptides

 Penicillin

Antibiotic

ACVS (NRPS),

IPNS (OX)

IPNS (OX),

PenM (transporter),

PaaT (transporter),

IAT (AT),

PCL (CoAL)

ACVS (NRPS),

PenV (transporter)

Cephalosporin

Antibiotic

CefP (transporter),

CefD1 (CoAL),

CefD2 (epimerase),

CefM (transporter)

CefT

CefT

 Fumiquinazolines

Cytotoxic

FmqB (OXR),

FmqC (NRPS)

FmqA (NRPS),

FmqE (MFS)

FmqD (OXR)

 Cyclosporin

Immunosuppressant agent

SimA (NRPS)

SimB (AlaR)

 Triacetylfusarinine C

Siderophore

EstB (HYD)

SidF (CoAT),

SidH (CoAH),

SidI (CoAL)

 Ferricrocin

Siderophore

SidL (AT)

Enb1 (Trans)

 Enterobactin

Siderophore

Sit1 (Trans)

 Ferroxamine B

Siderophore

Arn1p (Trans)

 Ferrichrome

Siderophore

 Amanitin

RNA polymerase II inhibitor

AbPOPB (POP)