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Table 2 Domain classes and domain families defined in the default synthaser rule file

From: Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases

Domain class

Domain family

Accession

Name

PSSM ID

PSSM Length

Threshold bitscore

A

cd05930

A_NRPS

341253

444

356.838

pfam00501

AMP-binding

366135

361

184.727

ACP

smart00823

PKS_PP

214834

86

33.3777

CHL00124

acpP

177047

82

85.8428

pfam14573

PP-binding_2

373139

96

112.899

pfam00550

PP-binding

376348

67

29.814

ACPS

COG0736

AcpS

223807

127

88.0777

PRK00070

acpS

234610

126

87.108

AT

smart00827

PKS_AT

214838

298

201.477

C

cd19535

Cyc_NRPS

380458

423

348.324

cd19533

starter-C_NRPS

380456

419

482.254

cd19538

LCL_NRPS

380461

432

638.54

cd19531

LCL_NRPS-like

380454

427

287.329

cd20480

ArgR-Cyc_NRPS-like

380470

406

714.278

cd19543

DCL_NRPS

380465

423

420.456

cd19544

E-C_NRPS

380466

413

476.159

cd19532

C_PKS-NRPS

380455

421

402.605

pfam00668

Condensation

334202

455

345.862

DH

pfam14765

PS-DH

379688

291

132.479

smart00826

PKS_DH

214837

167

76.8814

E

cd19534

E_NRPS

380457

428

363.495

ER

COG4981

COG4981

227314

717

1062.53

smart00829

PKS_ER

214840

287

250.768

cd05195

enoyl_red

176179

293

129.997

cd08270

MDR4

176231

305

268.471

cd05282

ETR_like

176645

323

224.079

KR

smart00822

PKS_KR

214833

180

83.3005

cd08950

KR_fFAS_SDR_c_like

187653

259

368.441

KS

smart00825

PKS_KS

214836

298

241.079

cd00833

PKS

238429

421

167.35

cd00829

SCP-x_thiolase

238425

375

147.795

TIGR01833

HMG-CoA-S_euk

273826

457

790.507

cd00751

thiolase

238383

386

222.354

PLN02287

PLN02287

215161

452

632.955

PRK07314

PRK07314

235987

411

601.393

TIGR03150

fabF

274452

407

525.512

COG0304

FabB

223381

412

152.8

cd00832

CLF

238428

399

503.431

cd00834

KAS_I_II

238430

406

285.201

cd00831

CHS_like

238427

361

242.515

cd00830

KAS_III

238426

320

212.4

MT

pfam08241

Methyltransf_11

369777

93

53.4302

pfam08242

Methyltransf_12

369778

96

37.7331

pfam13489

Methyltransf_23

372616

162

59.7422

pfam13649

Methyltransf_25

379312

96

36.008

pfam13847

Methyltransf_31

316372

150

67.449

cd02440

AdoMet_MTases

100107

107

29.3203

smart00828

PKS_MT

214839

224

133.695

PT

TIGR04532

PT_fungal_PKS

275325

324

202.466

SAT

pfam16073

SAT

374347

239

110.757

TE

smart00824

PKS_TE

214835

212

155.846

pfam00975

Thioesterase

366397

223

155.591

COG0657

Aes

223730

312

59.5636

pfam00561

Abhydrolase_1

366166

245

93.3378

TR

TIGR01746

Thioester-redct

273787

367

305.493

cd05235

SDR_e1

187546

290

229.845

cAT

pfam00755

Carn_acyltransf

376382

577

255.551