Table 1 Classification scheme of polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS)
Classification | Key domains | ||
|---|---|---|---|
Level 1 | Level 2 | Level 3 | |
Hybrid PKS-NRPS | Â | Â | KS, A or C |
NRPS | Â | Â | A, T, C |
NRPS-like | Â | Â | A |
Fatty acid synthase (FAS) | Â | Â | \(\beta\)-ketoacyl-ACP synthase |
| Â | Alpha subunit | Â | ACP, KR, KS |
| Â | Beta subunit | Â | SAT, ER, DH |
HMG-CoA synthase | Â | Â | HMG-CoA synthase |
Thiolase | Â | Â | Thiolase |
Polyketide synthase (PKS) | Â | Â | KS |
| Â | Multi-modular | Â | Multiple KS |
| Â | Type I | Â | KS, AT |
| Â | Â | Highly-reducing | ER, KR, DH |
| Â | Â | Non-reducing | SAT, PT |
| Â | Â | Partially-reducing | ER, KR or DH |
| Â | Type III | Â | CHS |