Fig. 2

Composition of the synthetic transcription factor SynX. The synthetic transcription factor SynX was constructed by fusing the N-terminal part of Xyr1, containing the Zn(II)2Cys6 binuclear cluster DNA-binding domain (yellow box), the C-terminal part of Ypr1, containing the transactivating fungal transcription factor middle homology region (blue box), and the ligand binding domain of the hERα (domain E, purple box)