Skip to main content
Fig. 1 | Fungal Biology and Biotechnology

Fig. 1

From: Functional production of human antibody by the filamentous fungus Aspergillus oryzae

Fig. 1

Schematic of the expression construct of adalimumab by A. oryzae and the genome PCR. Expression cassettes for heavy chain and light chain of adalimumab were introduced to niaD and sC loci, respectively. The dashed lines indicate the cleavage site of Kex2-like protease to separate the fusion protein. C, parental strains niaD or sC; 1, lD1-ada; 2, lDv10-ada; 3, AUT1-lD-v10-sD-ada; 4, lD-ΔP10-ada; M, DNA marker

Back to article page