Skip to main content
Fig. 2 | Fungal Biology and Biotechnology

Fig. 2

From: Transport systems, intracellular traffic of intermediates and secretion of β-lactam antibiotics in fungi

Fig. 2

Classic model of compartmentalization of the penicillin biosynthesis pathway in Penicillium chrysogenum. Both IPN and PAA are transported into peroxisomes (large green ellipse) by the PenM (blue ellipse) and PaaT (orange ellipse) transporters. The release of the α-aminoadipic acid from IPN (forming 6-APA) and the acylation mediated by the IAT (blue squares) reaction forming benzylpenicillin occurs in peroxisomes. The benzylpenicillin produced is transported to the cytosol and finally secreted to the external medium by a hypothetical ABC transporter (black rectangle) which has not been found so far. A vacuole is shown as a yellow ellipse exporting α-aminoadipic acid to the cytosol through the PenV transporter (purple ellipse)

Back to article page

Fungal Biology and Biotechnology

ISSN: 2054-3085

Contact us