Fig. 7

A. niger genes secG, ageB, and geaB have critical impacts on organic acid titres during submerged culture. From organic acid production medium in shake flask cultures, secreted citric acid and oxaloacetate were quantified using HPLC, and normalised to depleted glucose. Pairwise Student‘s t-tests were conducted between conditional expression mutant relative to the MA70.15 control at respective Dox concentrations (μg/ml). p values are indicated as (< 0.05, *). Note that mutants TC4.5 and TC5.6 performed comparably to their isogenic comparator, and are omitted from this figure for clarity