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Table 2 Summary of phenotypic consequences following expression of predicted ArfA GEFs or GAP using 0 or 0.2 µg/ml Dox

From: Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture

Phenotype

Mutant strain/Dox concentration

secG (0 µg/ml Dox)

geaB (0.2 µg/ml Dox)

ageB (0.2 µg/ml Dox)

Filamentous growth

−

+++

+++

Colony development

+

+++

+++

Pellet formation during protein production

−

+++

+++

Extracellular protein

−

+++

+++

Pellet formation during organic acid production

+++

+

+

Extracellular citric acid

+++

+++

+++

  1. Phenotypic deviations from the progenitor are indicated as dispensable (−), moderate (+) or essential (+++). For quantification, please see Figs. 2, 3, 4, 5, 6 and 7