Fig. 1

Co-expression networks for ageB, secG, and geaB reveal transcriptional coupling of these genes with Golgi vesicle trafficking and tricarboxylic acid cycle in A. niger. Query genes are given in grey diamonds, with co-expressed genes depicted as coloured circles. Genes used in multi-gene co-expression analysis are underlined. Grey lines indicate co-expression values above a Spearman cut-off of 0.5, which gives high confidence of robust co-expression throughout > 250 microarray experiments [10]. Examples of enriched GO-terms common to ageB, secG, and geaB co-expression networks relative to the A. niger genome are depicted. Gene name nomenclature from A. niger or the reference organism A. nidulans is given, and where not available, from S. cerevisiae. Benjamini–Hochberg false discovery rate corrected p-values for GO-enrichment are reported. As expected, these data show clear association of these genes with vesicles at the Golgi and with the TCA cycle