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Table 1 Putative proteins within the calbistrin cluster in P. decumbens

From: Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Name

P. decumbens locus

Size (aa)

BLASTP

Aver

%I

BLASTP

Aacu

%I

Conserved domain and notes

E-value

CalA

PENDEC_c013G00595

2910

OJJ08178.1

85.3

XP_020058113.1

78.1

PKS: KS, AT, ACP, DH, Cmet, KR, R

Note: similar to MlcA PKS

0.0

CalB

PENDEC_c013G07044

562

OJJ08177.1

84.9

XP_020058136.1

79.4

TIGR00711, drug resistance transporter,

Note: similar to MlcE MFS pump

4.1E−40

CalC

PENDEC_c013G06298

426

OJJ08176.1

74.6

XP_020058137.1

51.9

smart00066, GAL4-like Zn(II)2Cys6 DNA-binding domain

3.3E−05

CalD

PENDEC_c013G04601

494

OJJ08174.1

89.6

XP_020058121.1

76.1

No putative conserved domains detected.

 

CalE

PENDEC_c013G04259

494

OJJ08173.1

77.2

XP_020058122.1

49.8

pfam00067, Cytochrome P450

Note: similarity to MlcC monooxygenase

1.8E−36

CalF

PENDEC_c013G03789

575

OJJ08172.1

85.4

XP_020058123.1

75.4

COG0277, FAD/FMN-containing dehydrogenase

Note: similar to the bifunctional Sol5 flavin-dependent oxidase and alderase from Alternaria solani

2.7E−22

CalG

n/a

1056

OJJ08171.1

84.9

XP_020058124.1

72.8

pfam00067, Cytochrome P450, + CYPOR

Bifunctional: N-term cytochrome P450 and C-term cytochrome P450 reductase domains

2.5E−78

CalH

PENDEC_c013G02261

273

OJJ08170.1

82.6

XP_020058125.1

61.2

pfam08242, SAM dependent methyltransferase

Note: similarity to C-MET domain found in HR-PKSs: FUM1, EasB, LepA, ApdA and AzaB

1.6E−20

CalI

PENDEC_c013G00477

383

OJJ08169.1

82.7

XP_020058126.1

72.4

PRK06196, oxidoreductase (dehydrogenase)

1.1E−75

CalJ

n/a

418

OJJ08168.1

82.1

XP_020058127.1

68.5

pfam00144, Beta-lactamase (putative acyltransferase)

Note: similar to MlcH acyltransferase

1.7E−33

CalK

PENDEC_c013G03312

194

OJJ08167.1

83.0

XP_020058128.1

67.0

cd08249, enoyl reductase like

Note: similar to MlcG ER

3.5E−110

CalL

PENDEC_c013G00617

568

OJJ08166.1

88.1

XP_020058129.1

78.2

pfam00067, Cytochrome P450

5.7E−23

CalM

n/a

304

OJJ08165.1

89.8

XP_020058138.1

78.3

PRK06180, short chain dehydrogenase

1.5E−67

  1. The gene names calA–calM were defined in this study. The PENDEC_XXXXX accession numbers are as in the original publication of the genome, except for calG, calJ and calM. These new gene models were constructed using Softberry FGENESH supported with homologous genes in A. versicolor (Aver) and A. aculeatus (Aacu) (see Additional file 1: additional information 16 for protein sequences of P. decumbens CalG, CalJ and CalM proteins). Putative homologues of each of the P. decumbens CAL protein in A. aculeatus and A. versicolor were identify by BLASTP are here presented with accession umber, along with % identity at amino acid level (%I) along with the predicted conserved domains found in the protein and E-value for this prediction
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Fungal Biology and Biotechnology

ISSN: 2054-3085

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