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Table 3 Summary of highest CDP titres ever reported for bacterial and fungal expression hosts

From: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides

CDP Native producer Heterologous producer
Enniatin B 5 g/L (enniatin B and other derivatives)
F. oxysporum
Shake flask cultivation
[70]
1.1 mg/L
B. subtilis
Shake flask cultivation
[23]
950 mg/L
A. niger
Shake flask cultivation
[27]
4.5 g/L
A. niger
Bioreactor cultivation
[27]
Beauvericin 420 mg/L
F. oxysporum
Shake flask cultivation
[20]
74.1 ± 0.3 mg/L
S. cerevisiae
Shake flask cultivation
[24]
628.4 ± 211.1 mg/L
A. niger
Shake flask cultivation
[This study]
22.3 ± 1.5 mg/L
B. bassiana
Shake flask cultivation
[24]
8 mg/L
E. coli
Shake flask cultivation
[22]
113.4 mg/L
A. niger
Bioreactor cultivation
[This study]
Bassianolide 18.2 ± 0.6 mg/L
B. bassiana
In shake flask cultivation
[24]
26.7 ± 2.8 mg/L
S. cerevisiae
Shake flask cultivation
[24]
378.77 ± 59.74 mg/L
A. niger
Shake flask cultivation
[This study]
322.12 mg/L
A. niger
Bioreactor cultivation
[This study]
  1. For simplicity, respective strain names, genetic modifications and details on cultivation conditions (medium composition, cultivation time, feeding conditions, etc.) are not indicated for the different cell factories. This data can be extracted from the references given