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Table 2 Titres of beauvericin and bassianolide obtained from bioreactor cultivations

From: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides

Cultivation condition

Maximum titre (mg/L)

Beauvericin (run 1/run 2)

Bassianolide (run 1/run 2)

Standard cultivation condition

113.9/112.9

281.8/362.5

Precursor addition after 0 h

53.1/52.9

n.d.

No pH control

70.7/6.3

n.d.

  1. Titres of beauvericin and bassianolide produced in transformants DSc1.4 and SB19.23 under standard and modified cultivation conditions (for details see text). Bioreactor runs were performed in duplicates (run 1 and run 2)
  2. n.d. not done