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Table 1 Titres of beauvericin and bassianolide obtained in shake flask cultivations of A. niger

From: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides

Concentration of amino acid and hydroxy acid precursor (mM) Titre (mg/L)*
Beauvericin Bassianolide
0 0.45 ± 0.13 (DSc1.4) 1.04 ± 0.33 (SB19.23)
2.5 83.42 ± 5.24 (DSc1.4) 45.90 ± 11.05 (SB19.23)
15 293.62 ± 186.46 (DSc1.4) 378.77 ± 59.74 (SB19.23)
  628.4 ± 211.1 (DSc1.5)  
  1. Titres of beauvericin and bassianolide produced in the transformants DSc1.4, DSc1.5 and SB19.23 with and without precursor addition (d-Hiv and l-Phe for DSc1.4/DSc.15 and d-Hiv and l-Leu for SB19.23)
  2. Respective strains analysed are given in brackets. *: Titres are given in mean ± SD (n = 4 for strains DSc1.4 and SB19.23, n = 5 for strain DSc1.5)