Fig. 2
From: Basidiomycete non-reducing polyketide synthases function independently of SAT domains
Phylogenetic reconstitution of fungal non-reducing polyketide synthases (NR-PKSs) based on the KS domains. A maximum likelihood phylogenetic tree was constructed using predominantly biochemically characterized NR-PKSs (Additional file 1: Table S7). NR-PKS from Ascomycota are highlighted by the outer black, basidiomycete NR-PKSs by the outer red arc. The inner arcs denote color-coded the twelve NR-PKS clades. Ultrafast bootstrap values of ≥ 75 are shown as node labels. The partially reducing PKS 6-MSAS of Penicillium patulum [97] and ATX of Aspergillus terreus [98] were used as outgroup. The symbols at the tips of the branches refer to the active site motifs of the respective SAT domains (triangle: GxCxG /circle: GxSxG/square: GxGxG/red diamond: SAT-domain missing. Enzymes that have not yet been characterized biochemically in detail are highlighted with an asterisk (*)