Table 1 Mean inhibitory percentages of Scopularide (A and B) and Amphotericin B against Candida albicans and Aspergillus niger. and Clarithromycin against H. pylori. All tests were carried out in triplicate and values are expressed as mean ± SD
Sample concentration (µg/ml) | Mean inhibitory percentages against Candida albicans | ||
|---|---|---|---|
Amphotericin B | Scopularide A | Scopularide B | |
125 | 100 | 100 | 100 |
62.5 | 100 | 100 | 100 |
31.2 | 100 | 100 | 100 |
15.6 | 100 | 100 | 100 |
7.8 | 100 | 100 | 88.6 ± 1.9 |
3.9 | 100 | 100 | 65.1 ± 2.1 |
1.9 | 100 | 81.3 ± 1.3 | 49.3 ± 1.5 |
0.9 | 100 | 59.3 ± 0.6 | 28.1 ± 0.5 |
0.4 | 79.3 ± 1.3 | 34.2 ± 2.2 | 11.0 ± 2.1 |
0.2 | 54.3 ± 2.5 | 16.8 ± 1.7 | 4.9 ± 1.3 |
0 | 0 | 0 | 0 |
MIC | 0.9 | 3.9 | 15.6 |
Sample concentration (µg/ml) | Mean inhibitory percentages against Aspergillus niger | ||
|---|---|---|---|
Amphotericin B | Scopularide A | Scopularide B | |
125 | 100 | 100 | 100 |
62.5 | 100 | 100 | 82.1 ± 1.7 |
31.2 | 100 | 100 | 63.1 ± 2.2 |
15.6 | 100 | 86.3 ± 1.3 | 48.3 ± 1.5 |
7.8 | 100 | 71.2 ± 0.58 | 19.3 ± 2.1 |
3.9 | 100 | 56.3 ± 2.1 | 7.4 ± 1.6 |
1.9 | 83.2 ± 1.6 | 38.2 ± 1.5 | 0 |
0.9 | 69.2 ± 0.8 | 21.0 ± 0.6 | 0 |
0.4 | 54.1 ± 1.4 | 8.3 ± 1.2 | 0 |
0.2 | 39.2 ± 0.5 | 0 | 0 |
0 | 0 | 0 | 0 |
MIC | 3.9 | 31.2 | 125 |
Sample concentration (µg/ml) | Mean inhibitory percentages against H. pylori | ||
|---|---|---|---|
Clarithromycin | Scopularide A | Scopularide B | |
125 | 100 | 100 | 100 |
62.5 | 100 | 100 | 100 |
31.2 | 100 | 100 | 100 |
15.6 | 100 | 100 | 100 |
7.8 | 100 | 100 | 86.3 ± 1.3 |
3.9 | 100 | 92.4 ± 1.5 | 76.8 ± 2.1 |
1.9 | 100 | 84.7 ± 0.5 | 62.1 ± 0.9 |
0.9 | 92.4 ± 1.2 | 76.2 ± 0.5 | 52.1 ± 1.6 |
0.4 | 87.6 ± 0.58 | 54.1 ± 1.6 | 42.3 ± 2.2 |
0.2 | 81.3 ± 1.5 | 41.4 ± 1.2 | 36.3 ± 1.5 |
0 | 0 | 0 | 0 |
MIC | 1.9 | 7.8 | 15.6 |